https://www.sciencedirect.com/science/article/abs/pii/S1056872718306330?via%3Dihub
https://www.ncbi.nlm.nih.gov/pubmed/30190170?dopt=Abstract
TITLE:
Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes.
DESCRIPTION:
Related Articles
Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes.
J Diabetes Complications. 2018 Nov;32(11):1076-1084
Authors: Sommese L, Benincasa G, Lanza M, Sorriento A, Schiano C, Lucchese R, Alfano R, Nicoletti GF, Napoli C
Abstract
BACKGROUND: Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications.
METHODS: We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the epigenetic tags involved in type 1 and 2 diabetes onset was searched.
RESULTS: The epigenetic methylation maps of cord blood samples highlighted differences in the methylation status of CpG sites within the MHC genes between carriers of diabetes type 1 DR3-DQ2 and DR4-DQ8 risk haplotypes. β cell-derived unmethylated INS DNA showed the decline of β-cell mass preserving insulin secretion. Differentially methylated regions in pancreatic islets from type 2 diabetes covered PDX1, TCF7L2, and ADCY5 promoters during islet dysfunction. The recruitment of SET7 and SUV39H1 histone methyltransferases and LSD-1 lysine-specific demethylase-1 at NF-kβ-p65 promoter in vascular cells was involved in coronary heart disease. Neutrophil extracellular trap, activated by protein arginine deiminase-4, impaired wound healing from diabetic foot ulcers. MiR-199a-3p over-expression induced coagulative cascade, swelling and pain by a down-regulation of SERPIN-E2 in diabetic peripheral neuropathy. A DNA hypo-methylation and histone hyper-acetylation at MIOX promoter led an overexpression of ROS, fibronectin, HIF-1α, and NOX-4 associated with diabetic tubulopathy. A hypo-methylation of H3K4 at SOD2 promoter by LSD-1 increased ROS causing diabetic retinopathy.
CONCLUSIONS: Epigenetics played a relevant role in prevention, diagnosis, and treatment of diabetes.
PMID: 30190170 [PubMed – indexed for MEDLINE]
PMID:
PubMed:30190170
DATE FOUND:
10/09/19 01:34PM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/30190170?dopt=Abstract
