https://onlinelibrary.wiley.com/doi/full/10.1111/apm.12987
https://www.ncbi.nlm.nih.gov/pubmed/31344283?dopt=Abstract
TITLE:
L-serine: a neglected amino acid with a potential therapeutic role in diabetes.
DESCRIPTION:
Related Articles
L-serine: a neglected amino acid with a potential therapeutic role in diabetes.
APMIS. 2019 Oct;127(10):655-659
Authors: Holm LJ, Buschard K
Abstract
L-serine is classified as a non-essential amino acid; however, L-serine is indispensable having a central role in a broad range of cellular processes. Growing evidence suggests a role for L-serine in the development of diabetes mellitus and its related complications, with L-serine being positively correlated to insulin secretion and sensitivity. L-serine metabolism is altered in type 1, type 2, and gestational diabetes, and L-serine supplementations improve glucose homeostasis and mitochondrial function, and reduce neuronal death. Additionally, L-serine lowers the incidence of autoimmune diabetes in NOD mice. Dietary supplementations of L-serine are generally regarded as safe (GRAS) by the FDA. Therefore, we believe that L-serine should be considered as an emerging therapeutic option in diabetes, although work remains in order to fully understand the role of L-serine in diabetes.
PMID: 31344283 [PubMed – indexed for MEDLINE]
PMID:
PubMed:31344283
DATE FOUND:
09/19/19 06:01AM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/31344283?dopt=Abstract
