https://www.ncbi.nlm.nih.gov/pubmed/32236416?dopt=Abstract
TITLE:
PD-1 and PD-L1 Expression in Peripheral CD4/CD8+ T Cells Is Restored in the Partial Remission Phase in Type 1 Diabetes.
DESCRIPTION:
Related Articles
PD-1 and PD-L1 Expression in Peripheral CD4/CD8+ T Cells Is Restored in the Partial Remission Phase in Type 1 Diabetes.
J Clin Endocrinol Metab. 2020 06 01;105(6):
Authors: Li X, Zhong T, Tang R, Wu C, Xie Y, Liu F, Zhou Z
Abstract
CONTEXT: Partial remission (PR) in type 1 diabetes (T1D) is accompanied by downregulation of the immune response. Programmed cell death-1 (PD-1) and its ligand (PD-L1) are important immunosuppressive molecules, but their changes in the PR phase are unclear.
OBJECTIVE: We investigated the dynamic changes of PD-1/PD-L1 expression on T cells around the PR phase in T1D.
METHODS: Ninety-eight T1D patients were recruited cross-sectionally and grouped according to PR status into nonremitters (individuals who did not undergo PR during the disease course; n = 39), pre-PR (n = 15), mid-PR (n = 30), and post-PR (n = 14) subgroups. PR was defined according to C-peptide level ≥300 pmol/L or index of insulin-adjusted hemoglobin A1c ≤9 as recommended. Among all the 98 patients, 29 newly diagnosed individuals were prospectively followed up for 1 year. The dynamic changes of PD-1/PD-L1 expression, frequency of regulatory T cells (Tregs) and IL-35+ Tregs among peripheral CD4/CD8+ T cells were determined.
RESULTS: PD-1/PD-L1 on CD4+/CD8+ T cells showed a dynamic change around the PR phase: lowest in pre-PR phase, restored in mid-PR phase, and declined again in post-PR phase. Conversely, this pattern did not occur for nonremitters. Notably, PD-1 expression on CD8+ T cells in mid-PR was positively correlated with the length of the PR phase. The percentages of circulating Tregs and IL-35+ Tregs showed no relation to PR.
CONCLUSIONS: The PR phase is associated with restoration of PD-1/PD-L1 on CD4+ and CD8+ T cells, suggesting that PD-1/PD-L1 may be a potential target for prolonging this phase in T1D.
PMID: 32236416 [PubMed – indexed for MEDLINE]
PMID:
PubMed:32236416
DATE FOUND:
01/30/21 06:12AM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/32236416?dopt=Abstract
