https://onlinelibrary.wiley.com/doi/full/10.1111/imm.13048
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459770/
https://www.ncbi.nlm.nih.gov/pubmed/30712258?dopt=Abstract
TITLE:
Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes.
These observations suggest that YBG not only has a prebiotic property, but also an oral tolerogenic-adjuvant-like effect, and these features could be exploited for modulating autoimmunity in T1D.
DESCRIPTION:
Related Articles
Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes.
Immunology. 2019 05;157(1):70-85
Authors: Gudi R, Perez N, Johnson BM, Sofi MH, Brown R, Quan S, Karumuthil-Melethil S, Vasu C
Abstract
The dietary supplement and prebiotic values of β-glucan-rich products have been widely recognized and dietary approaches for modulating autoimmunity have been increasingly explored, we assess the impact of oral administration of high-purity yeast β-glucan (YBG) on gut immune function, microbiota and type 1 diabetes (T1D) using mouse models. Oral administration of this non-digestible complex polysaccharide caused a dectin-1-dependent immune response involving increased expression of interleukin-10 (IL-10), retinaldehyde dehydrogenase (Raldh) and pro-inflammatory cytokines in the gut mucosa. YBG-exposed intestinal dendritic cells induced/expanded primarily Foxp3+ , IL-10+ and IL-17+ T cells, ex vivo. Importantly, prolonged oral administration of low-dose YBG at pre-diabetic stage suppressed insulitis and significantly delayed the appearance of T1D in non-obese diabetic (NOD) mice. Further, prolonged treatment with YBG showed increased Foxp3+ T-cell frequencies, and a significant change in the gut microbiota, particularly an increase in the abundance of Bacteroidetes and a decrease in the Firmicute members. Oral administration of YBG, together with Raldh-substrate and β-cell antigen, resulted in better protection of NOD mice from T1D. These observations suggest that YBG not only has a prebiotic property, but also an oral tolerogenic-adjuvant-like effect, and these features could be exploited for modulating autoimmunity in T1D.
PMID: 30712258 [PubMed – indexed for MEDLINE]
PMID:
PubMed:30712258
DATE FOUND:
10/29/19 01:02PM
LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/30712258?dopt=Abstract
